Abstract

Applications of the micro Total Analysis System (μTAS) have been evolving over the last 20 years, including in the field of clinical diagnostics, in expectation of totally minimized system providing a reduction of reagent/sample consumption and a shortening reaction time. Based on our microfluidic chip technologies, We have developed fully automated immunoanalyzer “μTASWako i30” and fully automated genetic analyzer “μTASWako g1”.

In μTASWako i30, we employed LBA-EATA method which enables us to achieve high sensitivity and resolution in a short reaction time using capillary isotachophoresis (CITP) followed by capillary gel electrophoresis (CGE) in microfluidic channels. It allows sandwich immune-complex formation and detection of the complex by Laser-Induced Fluorescence (LIF). μTASWako i30 is approved as an IVD device in Japan, US, Canada and China, and has been on the world clinical diagnostics market since 2009.

In μTASWako g1, we employed polymerase chain reaction (PCR) followed by capillary gel electrophoresis (CGE) in microfluidic channels. μTASWako g1 is approved as an IVD device in Japan and has been on the clinical diagnostics market since 2016.